abstract：BACKGROUND:Delayed-release dimethyl fumarate (DMF) treatment can be associated with reduced lymphocyte and leucocyte counts, which might persist after DMF discontinuation. CASE PRESENTATION:We report the case of a patient with severe disease reactivation despite prolonged lymphopenia after DMF discontinuation. We desc...

journal_title：Acta neurologica Scandinavica

authors： Zecca C,Antozzi CG,Torri Clerici V,Ferrazzini M,Mantegazza RE,Rossi S,Gobbi C

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Cystatin C (CysC) is associated with many neurodegenerative disorders and autoimmune diseases, but its relationship with anti-N-Methyl-D-aspartate receptor (anti-NMDAR) encephalitis is unknown. METHODS:Serum levels of CysC were determined in 66 patients with anti-NMDAR encephalitis and 115 healthy controls....

journal_title：Acta neurologica Scandinavica

authors： Shu Y,Chang Y,Wu H,Li J,Cao B,Sun X,Wang J,Peng L,Hu X,Yu X,Qiu W

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVE:To explore the relationship between motor subtypes and drooling, and other risk factors associated with drooling in a large cohort of Chinese patients with Parkinson's disease (PD). METHODS:A total of 586 PD patients were enrolled in this study. Unified Parkinson's disease rating scale (UPDRS) and Hoehn & Ya...

journal_title：Acta neurologica Scandinavica

authors： Mao CJ,Xiong YT,Wang F,Yang YP,Yuan W,Zhu C,Chen J,Liu CF

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVES:We sought to assess the efficacy of subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD)-associated trunk posture abnormalities retrospectively analyzing data from 101 patients reporting mild-to-severe trunk posture abnormalities of a cohort of 216 PD patients treated with STN-DBS...

journal_title：Acta neurologica Scandinavica

authors： Artusi CA,Zibetti M,Romagnolo A,Rizzone MG,Merola A,Lopiano L

更新日期：2018-05-01 00:00:00

abstract：:Botulinum toxin serotype A (BoNT/A) was originally used in neurology for the treatment of dystonia and blepharospasms, but is now clinically used worldwide for the treatment of chronic migraine. Still, the possible mode of action of BoNT/A in migraine is not fully known. However, the mode of action of BoNT/A has been ...

journal_title：Acta neurologica Scandinavica

authors： Do TP,Hvedstrup J,Schytz HW

更新日期：2018-05-01 00:00:00

abstract：:Epileptic seizures are refractory to treatment in approximately one-third of patients despite the recent introduction of many newer antiepileptic drugs (AEDs). Development of novel AEDs therefore remains a high priority. Perampanel is a first-in-class non-competitive selective AMPA receptor antagonist with a unique me...

journal_title：Acta neurologica Scandinavica

authors： Tsai JJ,Wu T,Leung H,Desudchit T,Tiamkao S,Lim KS,Dash A

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVES:Ischaemic stroke is one of the leading causes of death and disability worldwide. Although the secondary preventive medication should be continued for life, its use commonly declines in time. This may lead to recurrent vascular events. In this study, we investigated if during a long follow-up period discontin...

journal_title：Acta neurologica Scandinavica

authors： Rijkmans M,de Jong G,van den Berg JSP

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVES:To evaluate the contribution of the demographical, clinical, analytical and genetic factors to brain signal intensity changes in T2-weighted MR images in amyotrophic lateral sclerosis (ALS) patients and controls. METHODS:Susceptibility-weighted and FLAIR sequences were obtained in a 3T MR scanner. Iron-rela...

journal_title：Acta neurologica Scandinavica

authors： Vázquez-Costa JF,Mazón M,Carreres-Polo J,Hervás D,Pérez-Tur J,Martí-Bonmatí L,Sevilla T

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder of the central nervous system (CNS). Interleukin (IL)-6 and IL-17A may play important roles in the pathogenesis of this disease. High-mobility group box protein 1 (HMGB1), a small but highly conserved ubiquitous protein, is rec...

journal_title：Acta neurologica Scandinavica

authors： Ai P,Zhang X,Xie Z,Liu G,Liu X,Pan S,Wang H

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVES:The importance of health-related quality of life (HRQoL) in multiple sclerosis (MS) is widely acknowledged. In 2015, a multicenter study was launched to assess the HRQoL and coping styles of chronically ill persons in Germany. The aims of this paper were (i) to describe how persons affected by MS assess thei...

journal_title：Acta neurologica Scandinavica

authors： Nickel S,von dem Knesebeck O,Kofahl C

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:We performed a systematic review and meta-analysis to evaluate the proposed association of restless legs syndrome (RLS) with cerebrovascular/cardiovascular outcomes. METHODS:We calculated the corresponding odds ratios on the prevalence of cerebrovascular/cardiovascular risk factors and standardized mean diff...

journal_title：Acta neurologica Scandinavica

authors： Katsanos AH,Kosmidou M,Konitsiotis S,Tsivgoulis G,Fiolaki A,Kyritsis AP,Giannopoulos S

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVES:To present clinical features at diagnosis for a large nationwide incident cohort of multiple sclerosis (MS) among those serving in the US military during the Gulf War era (GWE). MATERIALS & METHODS:Medical records and databases from the Department of Veterans Affairs (VA) for cases of MS with onset in or af...

journal_title：Acta neurologica Scandinavica

authors： Wallin MT,Culpepper WJ,Maloni H,Kurtzke JF

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:To validate the diagnosis of idiopathic intracranial hypertension (IIH) from the Swedish National Patient Register (NPR) and investigate the incidence of IIH, as well as co-morbidities and medication use in a large Swedish population-based sample. METHODS:We searched the NPR to find all patients ≥18 years ol...

journal_title：Acta neurologica Scandinavica

authors： Sundholm A,Burkill S,Sveinsson O,Piehl F,Bahmanyar S,Nilsson Remahl AIM

更新日期：2017-11-01 00:00:00

abstract：:Patients with multiple sclerosis have an increased risk of infections compared to the general population. The increased risk has been described for decades and is not alone attributed to the use of disease-modifying drugs, but secondary to the disability. The introduction of more potent immunomodulatory drugs may caus...

journal_title：Acta neurologica Scandinavica

authors： Celius EG

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVE:To assess seizure control and tolerability of eslicarbazepine acetate (ESL) as adjunctive therapy to one baseline antiepileptic drug (AED), in adults with partial-onset seizures (POS) with or without secondary generalization. METHODS:Multicenter, non-interventional, prospective cohort study conducted between...

journal_title：Acta neurologica Scandinavica

authors： Chaves J,Breia P,Pimentel J,Pelejão R,Carvalho M,Mateus P,Grebe H,Mestre A,Fernandes H,Sousa R,Gala A

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVES:This study aimed to investigate whether neurological disability status, heart rate variability (HRV), cardiorespiratory fitness (CRF) explained the variance in depressive symptoms in multiple sclerosis (MS). METHODS:Associations between CRF (via maximal oxygen uptake; VO2peak ), HRV indices of normalized ul...

journal_title：Acta neurologica Scandinavica

authors： Ensari I,Pilutti LA,Motl RW

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVES:Patients with Parkinson's disease (PD) and essential tremor (ET) have a higher risk of cognitive impairment than age-matched controls. Only a few small studies (11-18 subjects per group) have directly compared the cognitive profile of these conditions. Our aim was to compare the cognitive profile of patients...

journal_title：Acta neurologica Scandinavica

authors： Sánchez-Ferro Á,Benito-León J,Louis ED,Contador I,Hernández-Gallego J,Puertas-Martín V,Bermejo-Pareja F

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVE:Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe autoimmune disorder with a mortality of 5%-7%, but few studies have focused on the predictors of death in this disease. In this study, we aim to investigate predictors and causes of death in patients with anti-NMDAR encephalitis. METHODS:In ...

journal_title：Acta neurologica Scandinavica

authors： Chi X,Wang W,Huang C,Wu M,Zhang L,Li J,Zhou D

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVES:Post-stroke cognitive impairment (PSCI) has considerable impact on patients and society. However, long-term studies on PSCI are scarce and may be influenced by assessment methods and selection bias. We aimed to (i) assess the prevalence of long-term PSCI; (ii) compare two common cognitive assessment instrume...

journal_title：Acta neurologica Scandinavica

authors： Delavaran H,Jönsson AC,Lövkvist H,Iwarsson S,Elmståhl S,Norrving B,Lindgren A

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVES:Cerebrospinal fluid (CSF) from some patients with amyotrophic lateral sclerosis (ALS) has been demonstrated to significantly reduce the neuronal viability of primary cell cultures of motor neurons. We aimed to study the potential clinical consequences associated with the cytotoxicity of CSF in a cohort of pa...

journal_title：Acta neurologica Scandinavica

authors： Galán L,Matías-Guiu J,Matias-Guiu JA,Yáñez M,Pytel V,Guerrero-Sola A,Vela-Souto A,Arranz-Tagarro JA,Gómez-Pinedo U,García AG

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:The quality-of-life (QoL) perception by Parkinson's disease (PD) patients and their caregivers (CG) has not been studied in depth. OBJECTIVE:To examine patient/proxy agreements on the PD QoL Questionnaire (PDQ-39), the Scale of Quality of Life of Care-Givers (SQLC) and the Multidimensional Caregiver Strain ...

journal_title：Acta neurologica Scandinavica

authors： Balash Y,Korczyn AD,Knaani J,Migirov AA,Gurevich T

更新日期：2017-08-01 00:00:00

abstract：:For patients with Parkinson's disease (PD), excessive daytime sleepiness (PD-EDS) is a debilitating non-motor symptom and may be affected by mood symptoms, especially depression and anxiety. Few neuroimaging works have attempted to identify the neural features of PD-EDS, but various findings were reported. The purpose...

journal_title：Acta neurologica Scandinavica

authors： Wen MC,Chan LL,Tan LCS,Tan EK

更新日期：2017-08-01 00:00:00

abstract：INTRODUCTION:Cerebral small vessel disease (SVD) contributes to dementia and disability in the elderly, and may negatively affect stroke outcomes. We aimed to evaluate to what extent single features and global burden of SVD detected with magnetic resonance (MR) are associated with worse outcomes in patients with ischae...

journal_title：Acta neurologica Scandinavica

authors： Arba F,Inzitari D,Ali M,Warach SJ,Luby M,Lees KR,STIR\/VISTA Imaging Collaboration.

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVES:"Epileptic dementia" is reported in adults with childhood-onset refractory epilepsy. Cognitive deterioration can also occur in a "second-hit model". MATERIALS AND METHODS:We studied the clinical and neuropsychological characteristics of patients with cognitive deterioration (≥1 SD discrepancy between curren...

journal_title：Acta neurologica Scandinavica

authors： Breuer LEM,Grevers E,Boon P,Bernas A,Bergmans JWM,Besseling RMH,Klooster DCW,de Louw A,Mestrom RMC,Vonck K,Zinger S,Aldenkamp AP

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVES:The visual, somatosensory, and vestibular systems are critical for establishing a sensorimotor set for postural control and orientation. The goal of this study was to assess how individuals with a vestibular-related disorder keep their balance following prolonged stance on an inclined surface. We hypothesize...

journal_title：Acta neurologica Scandinavica

authors： Chong R,Berl B,Cook B,Turner P,Walker K

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Post-stroke cognitive impairment (PSCI) occurs commonly and is linked with development of dementia. We investigated the relationship between demographic, clinical and stroke symptoms at stroke onset and the presence of PSCI at 1 and 3 years after stroke. METHODS:We accessed anonymized data from the Virtual ...

journal_title：Acta neurologica Scandinavica

authors： Arba F,Quinn T,Hankey GJ,Inzitari D,Ali M,Lees KR,VISTA Collaboration.

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVES:Increased aqueduct cerebrospinal fluid (CSF) flow pulsatility and, recently, a reversed CSF flow in the aqueduct have been suggested as hallmarks of idiopathic normal pressure hydrocephalus (INPH). However, these findings have not been adequately confirmed. Our objective was to investigate the flow of blood ...

journal_title：Acta neurologica Scandinavica

authors： Qvarlander S,Ambarki K,Wåhlin A,Jacobsson J,Birgander R,Malm J,Eklund A

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVES:The objective was to investigate the incidence of multiple sclerosis (MS) as well as estimate the prevalence as of 1 January 2014 in the southeastern Norwegian county of Buskerud. MATERIALS AND METHODS:All patients with MS living in Buskerud county in Norway between 01 January 2003 and 01 January 2014 were ...

journal_title：Acta neurologica Scandinavica

authors： Simonsen CS,Edland A,Berg-Hansen P,Celius EG

更新日期：2017-04-01 00:00:00

abstract：:Dementia is a global health problem with a huge impact on the lives of those afflicted. There are several distinct diseases that are classified under the umbrella term "dementia" ranging from neurodegenerative disorders such as Alzheimer's disease to chronic infections of the central nervous system such as subacute sc...

journal_title：Acta neurologica Scandinavica

authors： Malek N,Baker MR,Mann C,Greene J

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Pain is common in post-stroke patients and has been shown to be associated with depression, fatigue, and decreased quality of life (QOL). However, studies examining different types of post-stroke pain are scarce. We investigated differences in the related factors and their QOL impacts between mus...

journal_title：Acta neurologica Scandinavica

authors： Choi-Kwon S,Choi SH,Suh M,Choi S,Cho KH,Nah HW,Song H,Kim JS

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Some recent studies have found an association between foetal malformations in earlier antiepileptic drug (AED)-exposed pregnancies and an increased hazard of such malformations in subsequent pregnancies. We investigated this matter further, and also considered the possible role of spontaneous abortions in pr...

journal_title：Acta neurologica Scandinavica

authors： Vajda FJ,O'Brien TJ,Graham JE,Hitchcock AA,Lander CM,Eadie MJ

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVE:To determine characteristics, clinical significance, frequency, and mimics of restless legs syndrome (RLS) in a cohort of Wilson's disease (WD, n = 42/f = 18), compared to healthy, matched controls. MATERIALS AND METHODS:Structured clinical interviews (patients and caregiving family members), repeated neurol...

journal_title：Acta neurologica Scandinavica

authors： Trindade MC,Bittencourt T,Lorenzi-Filho G,Alves RC,de Andrade DC,Fonoff ET,Bor-Seng-Shu E,Machado AA,Teixeira MJ,Barbosa ER,Tribl GG

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVES:The pathophysiology of migraine headaches is not clearly understood yet. The dopaminergic system has been hypothesized to be involved in migraine pathogenesis. The aim of this study was to investigate catechol-O-methyltransferase (COMT) polymorphisms and chronic headaches. We analyzed five single nucleotide ...

journal_title：Acta neurologica Scandinavica

authors： Takigawa H,Kowa H,Nakashima K

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVES:There are very few data available in the literature on the use of stiripentol in adults with Dravet syndrome (DS). DS cases are increasingly recognized in adulthood, and more children with DS now survive to adulthood. The aim of the study was to document the effectiveness and tolerability of stiripentol in a...

journal_title：Acta neurologica Scandinavica

authors： Balestrini S,Sisodiya SM

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:To explore the long-term effectiveness of rufinamide in managing Lennox-Gastaut Syndrome (LGS), other epileptic encephalopathies, and intractable focal epilepsies in adults and children in routine clinical practice. METHODS:A multicentre, retrospective chart review of patients prescribed adjunctive rufinamid...

journal_title：Acta neurologica Scandinavica

authors： Jaraba S,Santamarina E,Miró J,Toledo M,Molins A,Burcet J,Becerra JL,Raspall M,Pico G,Miravet E,Cano A,Fossas P,Fernández S,Falip M

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVES:To study the changes in the burden of informal caregivers of patients with disorders of consciousness (DOC) over time. MATERIALS AND METHODS:Short Form-12, Family Strain Questionnaire, Beck Depression Inventory and Coping Orientations to Problem Experiences were administered. RESULTS:Data collected on 216 ...

journal_title：Acta neurologica Scandinavica

authors： Covelli V,Sattin D,Giovannetti AM,Scaratti C,Willems M,Leonardi M

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVES:Botulinum neurotoxin (BoNT) injections in the salivary glands and radiotherapy (RT) on these glands are commonly used to alleviate severe drooling in patients with amyotrophic lateral sclerosis (ALS). This study compares BoNT type A with RT based on patient-rated evaluations. MATERIALS & METHODS:A prospecti...

journal_title：Acta neurologica Scandinavica

authors： Weikamp JG,Schinagl DA,Verstappen CC,Schelhaas HJ,de Swart BJ,Kalf JG

更新日期：2016-09-01 00:00:00

abstract：:Cognitive deficits have been reported in 45%-70% of patients with multiple sclerosis (MS). Like other symptoms of MS, cognitive deficits are highly variable. Slowed information processing and memory and learning dysfunction are regarded as the most frequent cognitive deficits in MS. Both white and gray matter damages ...

journal_title：Acta neurologica Scandinavica

authors： Hämäläinen P,Rosti-Otajärvi E

更新日期：2016-09-01 00:00:00

abstract：:Clinical measurement of intracranial pressure (ICP) is often performed to aid diagnosis of hydrocephalus. This review discusses analysis of ICP and its components' for the investigation of cerebrospinal fluid (CSF) dynamics. The role of pulse, slow and respiratory waveforms of ICP in diagnosis, prognostication and man...

journal_title：Acta neurologica Scandinavica

authors： Kasprowicz M,Lalou DA,Czosnyka M,Garnett M,Czosnyka Z

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVE:Patients treated with carbamazepine (CBZ) have increased serum levels of total cholesterol (TC), high-density lipoproteins (HDL), and low-density lipoproteins (LDL). We aimed to investigate whether these changes of serum lipids are reversible after CBZ withdrawal. MATERIAL AND METHODS:We used a prospective, ...

journal_title：Acta neurologica Scandinavica

authors： Lossius MI,Nakken KO,Mowinckel P,Taubøll E,Gjerstad L

更新日期：2016-09-01 00:00:00